Over the past few months, there has been an astonishing rate of scientific progress, with major implications for the management of the COVID-19 pandemic. In this 20-minute update, Dr Daniel Mahony and Gareth Powell, co-heads of the Polar Capital Global Healthcare Team, discuss the most up-to-date information they have gleaned from scientific papers and speaking to experts in the field, including vaccine developments, second-wave fears and the key catalysts they are watching over the coming weeks.